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The goal: to maximize therapeutic potential through synergy between components

doi: 10.1016/j.gde.2016.02.007 169 VahsenNCandeCBriereJJBenitPJozaNLarochetteNet al

Choi YK, Park KG

Tyuryaeva et al., 2023)

It reveals that altered glutathione and AA homeostasis induced by Trkb deletion in iSPNs is directly linked to early dopaminergic dysfunction and disrupted energy metabolism followed by age-dependent motor impairment and strongly supports the relevance of our model to elucidate the mechanisms underlying the vulnerability of iSPNs in neurodegenerative conditions

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