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Description
NOX family proteins are transmembrane proteins that transport the electrons from nicotinamide adenine dinucleotide (phosphate), NAD(P)H, to oxygen and generate superoxide anion as the intermediate product of oxidase and subsequently H 2 O 2 , as the product of dismutation of the superoxide

This dual approach explains why the compound produced stronger results than either ingredient would likely achieve alone

As these proteins pump H + ions into the acidic vesicles, more CQ diffuses from the cytoplasm into the lysosome following a pH gradient, causing an irreversible CQ accumulation, and increasing pH by trapping H + ions [266]

Diabetes Care 39 , 222230 (2016)
[DOI] [PMC free article] [PubMed] [Google Scholar] 224.Strozyk D, Launer LJ, Adlard PA, Cherny RA, Tsatsanis A, Volitakis I, Blennow K, Petrovitch H, White LR, and Bush AI

(2012) S-Nitrosylation signaling regulates cellular protein interactions, Biochim
