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Footnotes Conflicts of interest All authors report no conflict of interest

The surrounding skin remains unaffected, while the treatment leaves it smoother and more radiant

doi: 10.1097/PAS.0000000000000902 38 IsalesMCMohanLSQuanVLGarfieldEMZhangBShiKet al

Phospholipase Cdelta1 is required for skin stem cell lineage commitment

Data availability HAM10000 dataset: Abbreviations ANFIS: Adaptive neuro-fuzzy inference system AK: Actinic keratosis ANN: Artificial neural network AUC: Area under the curve BCC: Basal cell carcinoma CAD: Computer-aided diagnosis CRI: Radiograph image CNN: Convolution neural networks DF: Dermatofibroma DT: Decision tree FFNN: Feed-forward neural network GLCM: Gray level co-occurrence matrix GF: Gaussian filtering HKNN: Hierarchical KNN classifier ISIC: International Skin Imaging Collaboration KNN: K-nearest neighbor LBP: Local binary patterns LSTMs: Long short-term memory networks pyogenic gg: Pyogenic granulomas and hemorrhage RF: Random forest ReLU: Rectified linear unit ROC: Receiver operating characteristic RNN: Recurrent neural networks SCC: Squamous cell carcinoma SVM: Support vector machine WHO: World Health Organization ViTs: Vision transformers XAI: Explainable AI References Miller, K

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