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Malnutrition may act at least partially through an increase in fibroblast growth factor 21, which suppresses GH action and also increases serum IGFBP-1 concentration (18, 21)

In some embodiments, the use of multiparticulates (e.g., micronized particles) of a therapeutic agent, or an otic agent, allows for extended and/or sustained release of the therapeutic agent from any formulation described herein compared to a formulation or composition comprising non-multiparticulate (e.g., non-micronized) therapeutic agent

This avoids the digestive degradation problem altogether

& Cong, F

Kidney size rapidly normalizes within 3 to 6 months in acromegalic patients undergoing transsphenoidal surgery [91]

In the human retina, the concentration of carotenoids reaches a level between 0.1 and 1 mM in the central fovea [28], which is about 1000 times higher than in other tissues