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Herberts model, are outlined as follows: Promptly addressing a vitamin B12 deficiency is imperative to prevent potential irreversible neurological damage

NOS, nitric oxide synthase

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doi: 10.1002/mds.29369

and the interplay between the endoplasmic reticulum and actin to drive the contraction of the Drp1 protein to reduce the molecular spacing, leading to the rupture of the OMM and IMM and ultimately triggering mitochondrial fission (Giacomello et al., 2020