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Secondly, in other patients, such supplementation should not be started until 1 month of regular treatment with deferoxamine, and should be given only to patients receiving regular deferoxamine treatments
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Studies in Pink1 -deficient Drosophila and mouse models demonstrated that an early consequence of Pink1 deficiency is the disruption of complex I function, leading to mitochondrial membrane depolarization, increased sensitivity to apoptotic stress, and synaptic transmission deficits [90]

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