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In ovariectomized Wistar rats, colonic paracellular permeability was increased significantly and this was reversed by estrogen treatment (oestradiol benzoate) [89]

Pharmacol Rev 51: 761 [PubMed] [Google Scholar] Ehlers MD 2000

The former predominantly releases interferon- (IFN-) and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are less relevant to CRS pathogenesis, compared to interleukins (IL-6, IL-8, IL-10, IL-1a), tumor necrosis factor- (TNF-) and monocyte chemoattractant protein-1 (MCP-1), among others, which are released by CAR-T cells

Its a chain of 15 amino acids, and its stable enough to survive in your stomach, which is part of why its so effective