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Research in animal models suggests that nausea associated with peripheral GLP-1 receptor agonist administration involves activation of central GLP-1 receptors in these brainstem regions that control emesis

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Turkovic et al., 2004), as well as maintained NO system function against NOS blockade (L-NAME) or overfunction (L-arginine) (for review, see Sikiric et al., 2014)

Four pathways simultaneously

Benzodiazepines given at fixed dosing intervals are a common therapy for alcohol withdrawal management, and are well suited to ambulatory withdrawal, community residential and inpatient withdrawal settings

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