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The tumor bed was defined as the sum of 1) residual viable tumor (RVT), 2) necrosis, and 3) regression bed characterized by the presence of dense tumor-infiltrating lymphocytes (TIL) infiltrates, tertiary lymphoid structure (TLS), features of cell death (keratinous debris and giant cells), and tissue repair (neovascularization, fibrosis)

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Understanding how NMDARs regulate synaptic plasticity is therefore critical not only for deciphering the molecular basis of learning and memory but also for identifying mechanisms that drive disease pathogenesis
Cell 169 , 792806, (2017)

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