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263 Noteworthy, this approach could also help to design targeted covalent inhibitors that in turn could increase selectivity and, by using the structures predicted by AlphaFold, could be extended to the other subunits of the NOX complexes and used to design inhibitors based on peptide sequences from proteinprotein interfaces and, then, small molecule peptidomimetics

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3.1.1 Phytochemicals The polyphenols, especially flavonoids, are abundant antioxidants in human diets, primarily found in plant-based foods and linked to the Mediterranean diet, which is associated with lower cardiovascular disease mortality