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If patients treated with EGRIFTA SV develop glucose intolerance or diabetes, consider discontinuing EGRIFTA SV in patients who do not show a clear efficacy response

Annexure-II: Provides a detailed description of the steps involved in identifying and selecting metabolic ratios with diagnostic potential using the Biomarker Analysis module of MetaboAnalyst 6.0

Glutamine depletion by bacterial enzyme Crisantaspase and/or GS inhibitor methionine-L-sulfoximine (MSO) hinders the tumor growth of human HCC xenografts induced by CTNNB1-mutated HCC cell lines (Tardito et al., 2011)