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Overall, our data argued for a connection of accumulation of mutations in the ISDR with high RF in cell culture and the highly pathogenic course of liver disease after LTX

Therefore, the blockage of neutrophil differentiation by -toxin can cause a decrease in the absolute number of mature neutrophils without cytotoxicity

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Treatment may be discontinued in patients who do not achieve an early virological response at 12 weeks, although the decision should be individualized according to the tolerability of therapy, severity of underlying liver disease and demonstration of some degree of biochemical and/or virological response (I, III) 14

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