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doi: 10.1007/s10522-012-9400-9

Phase I Cytochrome P450 20 genes Transformation enzymes CYP1A1 CYP1A2 CYP1B1 CYP2A6 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP3A4 CYP3A5 CYP3A7 CYP4B1 CYP4F2 TBXAS1 (CYP5A1) CYP19A1 PTGIS (CYP8A1) FMO1 POR (CYPOR) Intermediate Phase 7 genes Oxidative stress CAT CDA DPYD G6PD OGG1 SOD1 MNSOD (SOD2) Phase II Conjugation 21 genes Solubilization and elimination NAT1 Acetylation NAT2 Acetylation UGT1A1 UGT1A3 UGT1A4 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2B7 UGT2B15 GSTM1 GSTM3 GSTP1 GSTT1 COMT MTHFR TPMT NUDT15 SULT1A1 SULT1A2 Transport 4 genes Substance transport APOE CFTR SLC15A2 SLCO1B1 +50 genes analyzed involved in liver detoxification How it works From DNA to a personalized detoxification profile A simple, non-invasive process designed for clinical practice

W.et al (2020)

It generally means the respondent or defendant did not contest (oppose) the case by appearing or filing a reply despite receiving notice from the court

[17] Oxidation: DIBP can be oxidized in the presence of ozone or other reactive oxygen species