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Consistent with the hypothesis that GS dysfunction in astrocytes impairs glutamatergic homeostasis and induces depression-like phenotypes, GS cKO mice exhibited significant anxiety, helplessness, and anhedonia in the OFT, TST, and SPT, respectively (Fig

doi: 10.1038/scientificamerican0385-114

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510,511 Their selectivity often involves strong hydrophobic interactions between the cap group and a large surface area on HDAC6, known as the L1 loop pocket
J.L.M.R
