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These mechanistic insights position ferroptosis induction as a promising therapeutic strategy for MM, where pharmacological modulation of ACSL4 activity/expression could augment therapeutic efficacy

Importantly, combining DKK1 antibodies with anti-PD-L1 treatment has yielded promising results in vivo, leading to significant 4T1 tumor volume reductions [165]

We analyzed three different endogenous controls, Gadph, Actb, and Rn18s , and several genes of interest, Vegfr2, Src, Nos2, Nos1, Nos3, Akt1, Kras, Mapk1, Srf, Foxo1, Nfkb1, and Egr1

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Actin is a fundamental protein that forms the cytoskeleton of cells, allowing them to maintain their shape and move