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Description
The neurological aspects of the disease are thought to arise from the accumulation of methylmalonyl- CoA due to the requirement of B 12 as a cofactor to the enzyme methylmalonyl-CoA mutase

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As a typical example, Yang et al

More welldesigned RCTs are still needed to gain a clearer understanding of the efficacy of these interventions 269 , 271 (Table 4)

Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma

This modification reduces the polarity of polyphenols, enhancing their permeability across lipid membranes and potentially increasing their half-life in the bloodstream [249]
