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This is one reason the condition often goes undetected for longer than it should

Chlamydocin, a fungal metabolite with a strong HDAC inhibitory potency, induces hyperacetylation of histones H3 and H4, resulting in G2/M cell cycle arrest and induction of apoptosis by activating caspase-3

Keywords including cellular senescence, aging, senolytics, senomorphics, SASP, and age-related diseases were used to identify relevant studies

Periodic boundary conditions were used with a cutoff of 10 for non-bonded interactions and the Particle Mesh Ewald method for long-range electrostatics

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