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This is particularly helpful for patients who find themselves fatigued when beginning a new exercise program or reducing their food intake
Notably, hypoxic conditions within the TME further amplify glycolytic flux through hypoxia-inducible factor 1 (HIF-1)mediated transcriptional activation of glycolysis-related genes, thereby establishing a metabolic landscape that favors HCC survival and progression [35,36,43,44] [Figure 1]
doi: 10.1016/s0891-5849(03)00102-3
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Zhang Z, Zhang F, An P, Guo X, Shen Y, Tao Y, et al
