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The systemic effects of AKI that may contribute to mortality have been extensively investigated in preclinical models

238,239 Senescent macrophages in the eyes secrete proinflammatory cytokines via STAT3 signaling, aggravating retinal damage and promoting neovascularization, a hallmark of AMD

The vitamin C-dependent enhancement of chemotaxis was thought to be mediated in part via effects on microtubule assembly [144,145], and more recent research has indicated that intracellular vitamin C can stabilize microtubules [146]

Conclusion Although defined as non-essential, L-serine plays critical roles in redox homeostasis, lipid metabolism, immune function, and mucosal defense against pathogens, highlighting its importance in maintaining intestinal homeostasis