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Zein/lactoferrin composite nanoparticles improved the pharmacokinetic profile of the TrkB agonist by increasing plasma C max and half-life ( t 1/2 ), ultimately ameliorating cognitive dysfunction in mice (Wang et al., 2023b)
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Low dose naltrexone (again-alone!) resulted in significant clinical improvement in 75% of these patients, with complete remission noted in 25%

tracking baseline + periodic values is a reasonable research observation

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