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Increased inflammation , which contributes to conditions like autoimmune diseases and chronic pain [5]

Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37

In addition, the uneven distribution of various enzymes across different organs and organelles further complicates the regulation of redox rhythms by oxidases and antioxidant enzymes

[DOI] [PMC free article] [PubMed] [Google Scholar] Fenton H

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Int J Mol Sci 26(6):2411 Prabha B, Sini S, Priyadarshini TS, Sasikumar P, Gopalan G, Joseph JP, Jithin MM, Sivan VV, Jayamurthy P, Radhakrishnan KV (2021) Anti-inflammatory effect and mechanism of action of ellagic acid-3, 3, 4-trimethoxy-4-O--L-rhamnopyranoside isolated from Hopea parviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages