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(2023, March 29)

The valproate pharmacokinetic profile following administration of divalproex sodium ER was characterized in a multiple-dose, non-fasting, open-label, multi-center study in children and adolescents

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These include so-called classical disorders like propionic academia (OMIM 606054) (53), various urea cycle disorders (89), and Sanfilippo syndrome (OMIM 252900, 252920) (90), as well as rarer disorders like succinic semialdehyde dehydrogenase deficiency (OMIM 271980) (91) and branched-chain ketoacid dehydrogenase kinase deficiency (OMIM 614901) (92)

Compared to WT and ACSS2 KO cells, DKO cells exhibited very low palmitate labeling (Figure 3G, Supplemental Figure 3H)