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Testing should also be done for B12 and vitamin D3 levels

Protein oxidation impairs vasodilatory function and cytoskeletal integrity in endothelial cells and smooth muscle cells, while lipid peroxidation disrupts vascular membranes [371]

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Together, they support the notion that precise modulation of NRF2, particularly in combination with ferroptosis inducers or existing systemic therapies, could overcome resistance and improve outcomes in HCC
10.1016/j.bcp.2012.02.003 Biochem