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Has been reported to cause overdoses and serious health issues, such as confusion, rapid heartbeat, slowed or stopped breathing, coma, and death

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In particular, B12 and B9 deficiencies can cause neural tube defects, which can prevent the spinal cord or brain from developing properly

compared the improvement of alcoholic polyneuropathy ( n = 84) in three treatment groups of capsules containing (A) 40 mg of B1, (B) 40 mg B1, 90 mg B6 and 250 g B12, (C) placebo over 8 weeks (total n = 84)

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Science 279 , 7476 (1998)