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Recent studies have found that BRAF/ERK inhibitors can release the feedback inhibition of upstream RTK and RAS signals, and the liberation of RTK and RAS signals can facilitate other signalling pathways, such as the PI3K/AKT/mTORC1 pathway, which improves cell growth and proliferation 181

doi: 10.1046/j.1525-1497.1997.07118.x

[DOI] [PubMed] [Google Scholar] Hua Y, Xi G, Keep RF, Hoff JT

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