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Studies have demonstrated that LLD is closely associated with energy metabolism disorders, potentially stemming from impaired mitochondrial function and chronic inflammation, leading to neuronal apoptosis and oxidative stress (38)

Nitric oxide related molecules that are produced in macrophage defense include nitric oxide intermediates and peroxynitrate (ONOO " )

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Pediatr Neurol 38(5):305313 Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Young IG (1981) Sequence and organization of the human mitochondrial genome

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