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cardiovascular, renal, and liver-disease trials read out through 2026 and 2027

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(Nature Communications) demonstrated that selective NNMT inhibition in diet-induced obese mice produced significant reductions in fat mass and improvements in insulin sensitivity without caloric restriction

It influences several overlapping repair pathways simultaneously: it may promote new blood vessel growth (VEGF), modulate the nitric oxide system, support collagen synthesis, and protect gut mucosal tissue