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Mechanistic data across tumor-cell, endothelial, neuronal and myeloid compartments support therapeutic interrogation of these axes, with fusion-directed TRK inhibition as standard of care where applicable and biomarker-guided investigation of pathway blockade in the broader population

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Other possible symptoms of a vitamin B12 deficiency include: Changes in the way you walk or move around (in your mobility) Disturbed vision Irritability Depression Mood changes Memory or judgement issues