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Environmental factors, such as infections, pollutants, smoke and detergents, can alter the skin barrier and trigger an inflammatory response through the generation of reactive oxygen species (ROS) (1922)

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For observational studies, the Newcastle-Ottawa Scale was used

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reported that intranasal delivery of human bone marrow MSC-derived A1-EXs post-SE suppressed pro-inflammatory cytokines (TNF- , IL-1, MCP-1, SCF, MIP-1, GM-CSF, and IL-12) while elevating anti-inflammatory factors, reducing microglial activation, and attenuating the inflammatory cascade (114)

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