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Overtreatment is associated with craniosynostosis in infants, may adversely affect the tempo of brain maturation, and may accelerate the bone age and result in premature epiphyseal closure and compromised adult stature [see Dosage and Administration (2.6) and Adverse Reactions (6)]

Of course, there are no side effects

Since endogenous VEGF-regulated angiogenesis may not be sufficient to better balance angiogenesis for optimal tendon repair, the application of exogenous VEGF or anti-VEGF antibody delivery can also regulate the balance of pro- and anti-angiogenic factors

Metabolism pathway Energy metabolism is responsible for sustaining fundamental biological activities

doi: 10.3389/fcimb.2017.00288 26 DainichiTMaekawaYIshiiKZhangTNashedBFSakaiTet al

Mar 2016;37(3):2789-2804