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Lastly, it is important to remark that ED could represent an early predictor of CV events and the diagnosis of vasculogenic ED at PDU, and particularly at dynamic PDU as the gold standard diagnostic tool, both in patients with or without additional CV risk factors and/or comorbidities, can help to recognize eventual arterial diseases in biggest distal vessels [35, 3941]

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(2) PKA-responsive lipase E/hormone-sensitive lipase (LIPE/HSL) contains multiple crucial phosphorylation sites that can be targeted by various kinases, particularly PKA, thereby leading to an augmentation of its enzymatic activity [77, 81]

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