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To validate the 48-h run-in diet, a coefficient of variation (CV) in baseline plasma TMAO was calculated across three fasting measurements (Phase I baseline, Phase II intervention 1 baseline, and Phase II intervention 2 baseline)

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Briefly, these include the following: Neuroprotection and neurotrophic effects

3 Risk factors

Preclinically, these inhibitors reduce infarct volumes and improve functional recovery, not merely by lowering lactate but by reprogramming cellular metabolism: forcing neurons to resurrect oxidative phosphorylation in salvageable penumbral regions and redirecting glucose toward the PPP to bolster NADPH-dependent antioxidant defenses [208, 209]

Clinically, the administration of CIT has been correlated with enhancements in endothelial function, arterial compliance, and exercise performance among geriatric populations as well as individuals suffering from metabolic or cardiovascular pathologies (29, 30)