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BPC-157 operates primarily through modulation of the nitric oxide system, growth factor receptor expression (particularly VEGF and FGF receptors), and interaction with the dopaminergic system

For example, a receptor may activate readily upon acute exposure, though under chronic exposure, the receptor may become overactivated and subsequently become downregulated either through decreased expression levels or cell surface presentation (Posner and Laporte 2010)

Nature of the relationship between vitamin B12 binding and cell uptake

Brunmark, A

doi: 10.1097/TP.0b013e3182126eeb 126 TesmerLALundySKSarkarSFoxDA

The same sites were used for repeat measurements