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Importantly, despite the inherent limitations of ex vivo and in vitro models, emerging in vivo and translational evidence supports the view that extracellular glycine availability dynamically regulates NMDA receptor function

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Given the many unknowns with high dose folic acid supplementation, particularly unmetabolized folic acid (as covered in my folate article), Im not able to draw any strong conclusions here

Without that, even strong supplement protocols struggle to make progress

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Xiao C, Puddicombe SM, Field S, Haywood J, Broughton-Head V, Puxeddu I, Haitchi HM, Vernon-Wilson E, Sammut D, Bedke N, Cremin C, Sones J, Djukanovi R, Howarth PH, Collins JE, Holgate ST, Monk P, Davies DE