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Description
1,2 SORT: KEY RECOMMENDATIONS FOR PRACTICE Figure 1 In the United States and the United Kingdom, the prevalence of vitamin B 12 deficiency is approximately 6% in persons younger than 60 years, and nearly 20% in those older than 60 years

Fumarate induces redox-dependent senescence by modifying glutathione metabolism
Proton pump inhibitors (PPIs) reduce stomach acid, which is needed for B12 absorption
Failure of VB 12 supply leads to inadequate synthesis of S-Adenosylmethionine (SAM), an allosteric activator of CBS, which is difficult to maintain the activity of CBS [12, 13]

EWAS were considered as inconsistent if they lacked a replication or validation cohort [24], while targeted studies were downgraded for this category if their results were in contradiction with the literature
For these patients, it is really important that they improve their reflux management with either higher doses or frequency of PPIs, and have a repeat scope in 6 months to reassess the area