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Treatment effect appears to be clinically evident starting from one to three months after treatment completion, with a subsequent progressive decrease of the achieved EF benefit over time, although some effects could be still detected up to five years after treatment [490,492,498]

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J Pathol Bacteriol (1961) 82:25766

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This is a centrally-initiated mechanism

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Boyle P'20, P'23 Richard A

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Acquired causes can be due to amalgam tattoo, melanocytic naevus, Addisons disease

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Cells 13 , 1838

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