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doi: 10.1038/srep28237

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Discovered in 1973 by Loren Pickart and shown in Nature to prolong liver cell survival 17 , it has since accumulated more than 50 years of peer-reviewed research on collagen and elastin synthesis, fibroblast activation, gene-expression modulation, and wound healing

Bioluminescent resonance energy transfer cellular imaging, in vitro assays, and cryo-electron microscopy have demonstrated the existence of internalized receptor complexes composed of a single GPCR, -Arr, and G proteins termed super-complexes that are capable of signaling from endosomes (Thomsen et al., 2016

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