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Description
A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction
doi: 10.1002/jps.22560
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A vendor could technically pass HPLC at 99% purity while filling vials with far fewer milligrams than labeled
A randomized trial of a low-trapping nonselective N -methyl-D-aspartate channel blocker in major depression
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