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In the next sections, we will briefly introduce thiazides, thiazide-like and loop diuretics from a historic perspective to illustrate how the success of one specific class of these diuretics in treating hypertension overshadowed their undesired metabolic effects and reduced our curiosity to study them to better understand their basic and clinical pharmacology

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The manner in which relapse occurs is poorly understood

In animal models of disease, carnosine or its derivatives, have shown efficacy to protect against complications of diabetes, ischemia/reperfusion injury, and atherosclerosis

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