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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Ravikumar S., Prabhu S., Vani R

Glycolysis inhibitors such as 2-DG and MCT inhibitors also demonstrate broad antitumor activity across multiple tumor models [151]

The initial formations of -ketoglutarate from glucose do require malateaspartate cycle activity, but there seem to be agreement that only 1520% of glutamineglutamate (GABA) cycle activity is connected with de novo synthesis of glutamate

Stephen J Genuis, Anna-Kristen J Siy

Although VT1021 exhibits an excellent safety profile, its objective antitumor activity has been modest [374]

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