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Description
It is also characterized by iron overload and downregulated expression of anti-oxidant proteins, including glutathione peroxidases (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase 4 (GPX4)

Gorba T, Wahle P (1999)

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The exact reason remains unknown yet it may result from two interacting elements

Correlation of p53 status with outcome of neoadjuvant chemotherapy using paclitaxel and doxorubicin in stage IIIB breast cancer
Dental intracanal application is not prohibited
