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Transporter dysfunction within the endolysosomal system leads to diverse systemic phenotypes
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CNS Drugs 2007;21(1): 1-11
Most of these SCC-associated NRF2 mutations harbor gain-of-function activity [50]
Quercetin is a powerful antioxidant that protects against ROS and has been shown to have remarkable protective benefits against diabetes, cardiovascular disease, inflammation, cancer, and damage to nerves and the eyes (Carrillo-Martinez et al
Specifically, ATF-4 enhances stress resistance and promotes longevity in worms by upregulating the transsulfuration enzyme CTH-2, increasing hydrogen sulfide (H 2 S) production ( In mammalian cells, stress conditions lead to the upregulation of CHAC1 through the action of ATF4
