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Additionally, Pb 2+ exposure downregulates synaptic proteins and interferes with brain-derived neurotrophic factor (BDNF) signaling, further impairing synaptogenesis and neuronal survival [42,82]

doi: 10.1016/S0002-9343(89)80154-8 94 HanJKimYSLimMYKimHYKongSKangMet al

doi: 10.1589/jpts.33.695 11 JaleelGShapheMAKhanARMalhotraDKhanHParveenSet al

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and Borutaite V., There Is no Evidence That Mitochondria Are the Main Source of Reactive Oxygen Species in Mammalian Cells, Mitochondrion 12, no

Through these circulating cells and metabolites, the gut microbiome may affect pulmonary immunity directly and possibly the makeup of the pulmonary microbiome
