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For instance, the heparin-binding domain of heparin-binding epidermal growth factor (HB-EGF) has been employed to enhance the retention of IGF-1 in cartilage in vivo , resulting in increased therapeutic efficacy in a rat medial meniscal tear model of OA

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Oxidative stress occurs when the body does not have ample antioxidant fighting power to combat free radicals

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The stimulated cells were fixed with 4% PFA in PBS for 30 min and stained with 0.2% crystal violet in 20% methanol

The recent identification of mutations in selenocysteine synthase causing progressive cerebello-cerebral atrophy underlines the central role of selenoproteins in brain development and protection from neurodegeneration