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Research protocols commonly include: Daily zinc supplementation Daily vitamin C supplementation alongside GHK-Cu-containing formulations
Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of acetaminophen

Chem Commun (Camb)

Studies presented by Wu et al

Active cancer or history of malignancy Pregnancy or breastfeeding Known peptide allergies Athletes subject to anti-doping testing (WADA prohibited) Raynauds disease or phenomenon Cold urticaria (hives from cold) Uncontrolled hypertension Peripheral vascular disease Open wounds (for local application) Pregnancy Cardiovascular conditions Diabetes (especially with neuropathy) Current infections Immunosuppression Blood clotting disorders Quality control issues represent perhaps the greatest practical risk with BPC-157