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While CYP1A1/1B1 induction resulted in the formation of (+/)- trans -7,8-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE), AKR1A1 overexpressing cells produced benzo [a] pyrene-7,8-dione (BP-7,8-dione)

doi: 10.3390/antiox12051069 121 SainiRKPrasadPLokeshVShangXShinJKeumYSet al

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This is because the glutathione molecule is delicate and easily destroyed during digestion

Its role is centered on healing, inflammation control, and tissue repair

Importantly, the abundance of amino acids in GshF -expressing tissues was largely comparable to those in GshF -null tissue, including the precursors of GSH synthesis, glutamate and glycine (Fig