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[DOI] [PubMed] [Google Scholar] 43.DeGraff JL, Gurevich VV, Benovic JL

It is also involved in immune function, metabolism, tissue building and repair, sperm cell formation, and certain enzyme functions

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However, emerging evidence from studies indicates a significant association between long-term metformin use and vitamin B12 deficiency, with prevalence rates ranging from 6% to 66%

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