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Bower, R

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J Biol Chem 265: 88548862, 1990

CRP is stronger during the early classical pathway activation of C1, C4, and C2 because the ligand-bound interaction with C1q leads to C3 convertase formation (a molecule that can trigger apoptosis in human coronary vascular smooth muscle cells), resulting in the activation of C1C4 convertases but with little stimulation of C5C9 convertases [80,127]

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