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In ESI-MS, the peptide solution is sprayed through a fine needle under high voltage, creating charged droplets

Chapter 14 Red Blood Cell and Bleeding Disorders

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

The procedure is quick and nearly painless, often taking less than 10 minutes from start to finish

According to the recently proposed Acidic Exposure model, acidic residues alternate with hydrophobic residues within an acidic TAD, and electrostatic repulsion among the acidic side chains exposes the hydrophobic residues to solvent, allowing coactivator engagement 68,69

doi: 10.1177/014860719702100275