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This duality underscores the importance of context-specific modulation and highlights the current lack of reliable biomarkers to guide patient selection for autophagy-targeting combinations

Liu JL, Chen FF, Lung J, Lo CH, Lee FH, Lu YC, et al

2018YCGC002 to JC)

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After TBI, the NAD-dependent deacetylase sirtuin-1 (Sirt1) that promotes Nrf2 is downregulated, reducing Nrf2 signaling and Nrf2-induced transcription of antioxidant, antiapoptotic and metabolic genes [80]

It was a nontrivial task to review a manuscript of this size and they were both constructive and rigorous in their work